Mewgenics throws players into a world of roguelike chaos, where every run could be your last. But one threat doesn’t even wait for a new game: Guillotina, a towering, blade-wielding horror, doesn’t content herself with dungeons or caves. She comes to your door.
Most bosses in Mewgenics demand quick reflexes and precise strategy during a run. Guillotina, however, demands something far more personal: the sacrifice of your most powerful retired cats. With seven in-game days to prepare, players must carefully select, equip, and position their feline forces before the inevitable siege. The stakes couldn’t be higher—lose, and your cats meet a fate worse than a failed breeding attempt.
The misconception is that Guillotina is just another tough fight. In reality, she’s a test of foresight, resource management, and tactical placement. Unlike other encounters, where you can swap out strategies mid-battle, Guillotina’s assault begins the moment you confirm your team. There’s no do-over.
- Guillotina arrives after beating the Boneyard stage, invading your home.
- You have seven in-game days to prepare—retire strong cats, breed for stats, and gather gear.
- Only four retired cats can defend your home; no substitutions allowed.
- Her attacks range from AoE slashes to cat-napping inhales, demanding spread-out positioning.
- Victory grants the Throbbing Gristle quest item and upgrades your defenders to ‘ultra’ retired status.
Preparation starts long before the countdown begins. The game gives players a week to refine their retired roster, but the real work happens in prior runs. Breeding high-stat cats—particularly those with Strength, Constitution, and Intelligence—ensures a fighting chance against Guillotina’s relentless damage. Comfort stat matters too; neglected cats may turn on each other overnight, leaving you with fewer options when the time comes.
Gear is just as critical. Guillotina’s health pool sits at a staggering 500 HP, and her attacks—from ground-pounding leaps to inhaling cats mid-battle—require both defensive positioning and sustained damage. Armor and weapons found in dungeons become non-negotiable. A Hunter with Marked and Arrow Flurry can melt her from range, while a Fighter paired with high Constitution can weather her melee onslaught. Clerics and Necromancers, meanwhile, provide the lifeline needed if the fight drags on.
The battle itself is less about outmaneuvering Guillotina and more about survival. Her Slice attack covers two tiles, knocking back adjacent cats—so clustering your team is a death sentence. Groundpound deals AoE damage in a 4x4 grid, while Toss hurls a cat across the arena, leaving them vulnerable. The most insidious move? Inhale, which sucks a cat into her maw. The victim can Flail for a 25% chance to escape, but until then, they’re out of the fight. Spreading your cats thin is the only counter.
Speed and critical hits accelerate the inevitable. A Hunter with high Luck can land 50+ damage per turn, whittling down Guillotina’s health before her attacks claim another cat. Stuns and bleed effects buy precious seconds, while melee classes like Fighters benefit from Alpha or other speed-boosting skills to re-engage after a Toss.
Defeating Guillotina isn’t just a boss kill—it’s a rite of passage. The Throbbing Gristle, a quest-critical item, awaits the victorious, along with a permanent upgrade for your defenders: a glowing crown marking them as ‘ultra’ retired. They can’t fight again, but they remain valuable for breeding, ensuring their legacy lives on even after the battle.
The lesson? Guillotina isn’t just another raid boss. She’s a reminder that in Mewgenics, even your home isn’t safe—and neither are the cats you’ve spent weeks perfecting. Prepare carefully, or risk losing them forever.
